A doctor from IU has developed a technique to stimulate the brain with RF signals with the potential of treating Alzheimer's in humans. Because this method has previously been tested, the likelihood of having positive effects on humans is high. The goal is to lower Aβ and stop disease progression using a safe, noninvasive strategy. Currently, a treatment has not been developed for humans due to the poor penetration depth of EMF devices to the human brain, thus making it essentially ineffective in reaching deep memory areas. The only known side effect is a body temperature rise of 1.3 degrees in the test mice. Temperature rises over 0.5 degrees cause tissue injury which is hoping to be avoided with the new bird cage design.
As of now, a biological team has found PHB cultures treated at 64MHz had a substantial decrease in Aβ levels over a span of 14 days. 64MHz was also found to have deep skin penetration delivering the appropriate power to the affected AD areas. A minimum of 0.4 W/Kg was the minimum amount of SAR required to not develop cellular toxicity. Having a bird cage to safely deliver the same SAR levels to all memory areas across the human brain is the new task at hand. Once this bird cage is developed, a personalized AI device will be constructed to give those with AD the best treatment for their specific degeneration rate.
Being able to diagnose and treat AD will help millions of families as it is the most common neurodegenerative dementia across the world. Not only will individuals be saved, but AD costs the nation $321 billion and is expected to go up in the coming years. Current treatments such as NMDA receptor antagonists, cholinesterase inhibitors or monoclonal antibodies merely are standard care but do not improve cognition. This led to the development of using repeated electromagnetic field stimulation to lower Aβ levels and stop disease progression to potentially save $1 trillion US dollars by 2050.
The team will be focused on providing data of the proposed solution by the IU medical team. The proposed treatment shows promising results in animal testing. The goal is to create a less invasive treatment or cure for the neurodegenerative disease Alzheimer's. The team will be collecting data on cases to train an AI model with the dataset. Secondly, the team will be creating the proposed treatment device to test safety and provide data to the medical staff discussing treatment safety.